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Ascomycin macrolactams belong to a new group of immunosuppressive, immunomodulatory and anti-inflammatory agents. Due to their chemical nature they are water-soluble and therefore, in principle, suitable for topical treatment of dermatological disorders.

Ascomycin macrolactam derivative has been approved for short-term and intermittent long-term therapy in the treatment of mild to moderate atopic dermatitis

Ascomycin references

• The ascomycin macrolactam pimecrolimus (Elidel, SDZ ASM 981) is a potent inhibitor of mediator release from human dermal mast cells and peripheral blood basophils
• Discovery of ascomycin analogs with potent topical but weak systemic activity for treatment of inflammatory skin diseases
• Studies on an immunosuppressive macrolactam, ascomycin: synthesis of a C-33 hydroxyl derivative
• Ascomycin macrolactam derivative SDZ ASM 981 inhibits the release of granule-associated mediators and of newly synthesized cytokines in RBL 2H3 mast cells in an immunophilin-dependent manner
• Effectiveness of the ascomycin macrolactam SDZ ASM 981 in the topical treatment of atopic dermatitis

ASCOMYCIN AT FERMENTEK